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. Author manuscript; available in PMC: 2009 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Dec 3;18(2):494–497. doi: 10.1016/j.bmcl.2007.11.104

Figure 1.

Figure 1

Compound 1 is a tetrahydroquinoline-based PFTI that is metabolized by cytochrome P450 to give compound 2. Compound 3 shows the general structure of the 2-oxo-tetrahydro-1,8-naphthyridine-based PFTIs prepared in the current study.