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. Author manuscript; available in PMC: 2009 Jan 15.

Published in final edited form as: Bioorg Med Chem Lett. 2007 Dec 3;18(2):494–497. doi: 10.1016/j.bmcl.2007.11.104

Scheme 1 — Reagents, conditions and yields: (a) SOCl₂, EtOH, 80%; (b) Et₃N, DMF, 60%; (c) LiAlH₄, THF, 70%; (d) MnO₂, CH₂Cl₂, 75% ; (e) Tetramethylguanidine, CH₂Cl₂, 65%; (f) H₂/Pd-C, CH₃OH, 50%; (g) Br₂, CH₃COOH, 65%; (h) Zn(CN)₂, Pd(PPh₃)₄, 35%; (i) 20% CF₃COOH, CH₂Cl₂, 100%; (j) R²-CHO, NaCNBH₃, CH₃OH, 55–60%; (k) R¹-SO₂Cl, DIPEA, CH₂Cl₂, 15–20%.