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Scheme showing the seesaw cross-talk, between MEK/ERK and p38 pathways during the differentiation of Saos-2 cells. Growth factors contained in FBS activate both ERK and p38 pathways. The MEK/ERK pathway suppresses differentiation and is inhibited by PD98059. In contrast, the p38 pathway enhances differentiation and is inhibited by SB203580. PD98059 inhibits ERK and activates p38, whereas SB203580 inhibits p38 and activates ERK
