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. 1998 Jun 9;95(12):7115–7120. doi: 10.1073/pnas.95.12.7115

Figure 2.

Figure 2

Pretreatment with ATA prevents ischemia-induced down-regulation of GluR2 mRNA in CA1 pyramidal neurons of gerbil. Determinations at 48 h after 5 min of ischemia, 1 h after i.c.v. injection of ATA. Photomicrographs of autoradiograms of GluR1, GluR2, and NMDAR1 mRNAs detected by in situ hybridization in coronal sections at the level of the hippocampus. Levels are essentially uniform through the hippocampal cell layers in sham-operated (control) animals (Left). (A–C) After 48 h, GluR1 mRNA is at similar levels in sham-operated gerbils (A) and in gerbils injected i.c.v. with either saline (B) or ATA (C) 1 h before 5 min of ischemia. (D–F) GluR2 mRNA was dramatically reduced in CA1 (arrowhead), but not in the other hippocampal regions after ischemia with saline pretreatment (E). Pretreatment with ATA prevented the ischemia-induced decrease in GluR2 mRNA in CA1 and had no effect on GluR2 expression in CA3 and dentate gyrus (F). (G–I) NR1 mRNA was unaffected by ischemia with saline (H) or with ATA pretreatment (I).