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. 1998 Jun 9;95(12):7115–7120. doi: 10.1073/pnas.95.12.7115

Figure 3.

Figure 3

Expression of GluR1, GluR2, and NR1 mRNAs in gerbil hippocampus 48 h after global ischemia with and without ATA pretreatment. Ischemia was followed by down-regulation of GluR2 specific to CA1; this effect was blocked by i.c.v. injection of ATA 1 h before the ischemic episode. (A) CA1. (B) CA3. (C) dentate gyrus. Optical density values are plotted as percentage (± SEM) of densities in sham-operated animals. Gerbils were injected i.c.v. with either saline (n = 4, bars labeled ischemia) or ATA (n = 8; bars labeled +ATA) 10 min before induction of 5 min of ischemia. Four additional animals subjected to ischemia but with no injection are included with the saline-injected animals from which they did not differ. DG, dentate gyrus. ∗, P < 0.01 GluR2 in CA1 ischemia vs. sham-operated and vs. ATA- injected.