Table 2.
Fold Increase in
|
Fold Decrease in
|
|||
---|---|---|---|---|
Receptor
|
Fold Induction
|
Vmax |
Partial Agonist Activity
|
EC50 |
PR (0.3ng) | 0.84 ± 0.08
(0.11) |
1.85 ± 0.15
(0.0012) |
1.28 ± 0.05
(0.0016) |
2.58 ± 0.37
(0.0055) |
PR (10 ng) | 0.54 ± 0.06
(0.0014) |
1.47 ± 0.22
(0.10) |
0.95 ± 0.07
(0.51) |
3.07 ± 0.64
(0.032) |
GR (endog.) | 1.14 ± 0.08
(0.19) |
2.74 ± 0.74
(0.10) |
0.56 ± 0.18
(0.087) |
1.15 ± 0.05
(0.051) |
The average values listed are from N independent experiments similar to those of Fig. 3 but now in 1470.2 cells. The experiments were performed and analyzed as in Table 1 with the indicated amounts of transfected PR plasmid or endogenous GR (n = 7 for 0.3 ng PR, = 5 for 10 ng PR, and = 4 for GR). P values for statistical significance are in parentheses.