Table 3.
Summary of Cofactor Interactions with PR vs. GR
| EC50 |
% Agonist Activity
|
Vmax |
|||||
|---|---|---|---|---|---|---|---|
| Factor
|
Response of PR vs. GR
|
PR
|
GR
|
PR
|
GR
|
PR
|
GR
|
| A. GME | Different | = | - | = | + | = | + |
| GMEB-2 | |||||||
| Low | Different | - | ≥ | + | - | - | - |
| High | Same | + | + | - | - | - | - |
| Ubc 9 | More sensitive | - - | - | + | ≈ | + | + |
| STAMP | Same† | - | - | + | + | + | + |
| † different domains | |||||||
| B. Receptor | Same | - | - | + | + | + | + |
| TIF2 | Same | - | - | + | + | + | + |
| NCoR | Different | - | + | + | - | - | - |
| SMRT | Different | + | - | - | + | ≈ | - |
Summary is a composite of results from (A) this study and (B) previous studies for PR and GR (Szapary et al., 1996; Szapary et al., 1999; Giannoukos et al., 2001), TIF2 (Szapary et al., 1999; Giannoukos et al., 2001), and NCoR and SMRT (Song et al., 2001). Definition of symbols describing effect on parameters following addition of various factors: --, much less than; -, less than; =, equal to; ≈, approximately equal to; ≥, greater than or equal to; +, more than.