FIGURE 8.

Mortality is accelerated in α_Dβ₂-deficient mice infected with S. typhimurium. WT or α_D^−/− mice were infected with S. typhimurium by the i.p. route (10⁵ bacteria/animal). Groups of 10 α_D^−/− and 10 WT animals were studied in each of three separate experiments. The pooled survival data for 30 animals of each genotype are shown. The difference between the cumulative survival plots was significant (p = 0.0004). Control sham-infected mice that received vehicle alone were studied in parallel; no sham-infected animals died.