Table 4.
Comparison by Spectrographic Phenotypes - Titration
| Measure | Successful Titration n=42 | Failed Titration n=35 | P |
|---|---|---|---|
| Conventional polysomnographic analysis | |||
| Total Sleep Time (TST, min) | 379.6 ± 70.1 | 220.6 ± 48.6 | 0.04 |
| Wake After Sleep Onset | 9.7 ± 4.7 | 27.9 ± 11.2 | 0.02 |
| Sleep Efficiency | 90.6 ± 8.1 | 72.4 ± 9.6 | 0.01 |
| Stage I % TST | 8.5 ± 2.2 | 16.9 ± 6.2 | 0.01 |
| Stage III+IV % TST | 18.9 ± 4.4 | 4.6 ± 3.1 | < 0.001 |
| Stage REM %TST | 18.9 ± 7.2 | 18.1 ± 6.2 | 0.1 |
| Arousal index (per h of sleep) | 18.8 ± 4.1 | 32.5 ± 6.9 | 0.001 |
| Apnea Hypopnea Index (per h of sleep) | 8.4 ± 2.5 | 33.9 ± 7.8 | < 0.001 |
| Central Apnea Index (per h of sleep) | 0.7 ± 1.2 | 15.9 ± 6.4 | < 0.001 |
| Obstructive Apnea Index (per h of sleep) | 1.7 ± 0.9 | 3.6 ± 2.1 | 0.04 |
| Periodic Limb Movement Index (per h of sleep) | 5.7 ± 3.2 | 6.3 ± 3.7 | 0.2 |
| Minimal nocturnal oxygen saturation | 96.3 ± 3.3 | 88.8 ± 6.4 | 0.01 |
| Spectrographic analysis | |||
| Low Frequency Coupling (% of spectral windows) | 12.6 ± 4.7 | 56.7 ± 7.3 | < 0.001 |
| High Frequency Coupling (% of spectral windows) | 72.2 ± 9.2 | 21.9 ± 4.6 | < 0.001 |
| e-LFCBB (% of spectral windows) | 14.3 ± 3.4 | 28.6 ± 7.9 | < 0.01 |
| e-LFCNB (% of spectral windows) | 1.4 ± 2.1 | 19.2 ± 5.4 | < 0.001 |
| Very low frequency coupling, % of spectral windows | 14.3 ± 4.1 | 20.8 ± 6.3 | 0.01 |
Total Sleep Time includes split night studies (40/77).