Figure 3.

Fifty intrinsically oscillating neurons were simulated for 10 s under 4 conditions with different synaptic strengths (shown in order of decreasing synaptic strength from top to bottom). Left, phase angle relative to the signals average phase, calculated using the Hilbert transform (see Methods). Synchronization between neurons can be seen to decline with decreasing synaptic strength. Specifically, the phase synchronization index was 0.885 ± 0.074, 0.383 ± 0.139, 0.154 ± 0.078, and 0.113 ± 0.057 for the 4 decreasing synaptic strength conditions. A 1-way analysis of variance revealed a significant effect of synaptic strength on the phase synchronization index (F_3,39996 = 147555.87, P < 0.001). Middle, population average membrane potential. Note that spikes occurred in all cases but may not be evident due to averaging. Right, power spectrum (0–10 Hz).