Figure 7.
vMYXV-M64R is highly attenuated in a mouse intranasal infection model while vMYXV-M62R is virulent. (A). Groups of 5 Balb/c mice were infected intranasally with 105 PFU of indicated viruses or mock infected with the same volume of PBS. The mice were then monitored daily for their body weights. For each group, the average of the percentage of body weight change and standard deviation are shown. (B). At day 7 post infection, mice were euthanized and their lungs and spleen were harvested. Approximately 16 mg of spleen and 5 mg of lung from each mouse were homogenized and their viral loads were determined by plaque assay on VERO cells. Error bars represent standard deviation.