Table 1.

Levels and Molar Ratios for IGF-I, IGFBP-3 and ALS in Healthy, Non-Pregnant Mice

		Age (wks)1
		1	2	4	8	20	32
IGF-I (ng/mL)
male	mean±SD	53± 8	158±30	594±84	636±48	522±37	395±64
	median	56	158	580	638	512	398
	range	42–63	123–192	475–694	550–692	483–589	315–517
female	mean±SD	102±21	211±66	548±77	417±61	539±78	535±88
	median	93	200	542	414	541	522
	range	87–126	156–288	418–666	348–537	389–655	396–664
IGFBP-3 (ng/mL)
male	mean±SD	1213±173	2267±164	2800±428	2248±338	1808±314	1102±168
	median	1245	2231	2707	2208	1673	1070
	range	946–1508	2048–2614	2205–3519	1781–2925	1407–2239	871–1352
female	mean±SD	1078±108	2643±232	2699±398	1925±439	1776±522	1653±337
	median	1097	2531	2672	1827	1687	1638
	range	867–1217	2444–3166	1998–3441	1469–2965	1212–3055	1108–3296
ALS (ng/mL)
male	mean±SD	1052±237	2090±201	4721±281	5371±785	4484±385	3599±483
	median	1001	2026	4654	5328	4408	3490
	range	731–1534	1858–2433	4443–5263	4469–6626	4004–5075	2910–4521
female	mean±SD	1238±268	2360±738	4860±547	3741±910	4107±808	4121±638
	median	1167	2199	4673	3596	4140	4074
	range	905–1753	1481–3826	4520–5934	2632–4738	2813–5132	3328–5225
IGF-1 to IGFBP-3 molar ratio (%)
male	mean±SD	23±8	44±12	80±7	105±16	112±18	141±28
	median	22	42	80	107	115	143
	range	16–40	27–59	71–94	85–128	84–135	105–182
female	mean±SD	36±3	52±10	79±8	91±10	122±22	131±44
	median	35	49	80	90	124	122
	range	33–40	44–66	64–91	78–109	83–156	93–232
IGFBP-3 to ALS molar ratio (%)2
male		270	254	139	98	95	72
female		204	262	130	120	101	94
IGF-I to ALS molar ratio (%)2
male		46	69	114	107	106	100
female		75	81	102	101	119	118

¹n=6–8 for each sex at each age

²ALS levels were from a different population. Therefore, the IGFBP-3 and IGF-I to ALS molar ratios are estimated from the mean levels for each age and sex.