Table 2.
Levels and Molar Ratios for IGF-I, IGFBP-3 and ALS in Pregnancy and Postpartum
| Pregnancy (8 wks old at impregnation) |
Non-pregnant | |||
|---|---|---|---|---|
| 10 d gestation n=5–8 | 18 d gestation n=5–8 | 4 d postpartum n=8 | 8 wk old female n=8 | |
| IGF-I (ng/mL) | ||||
| mean±SD | 354±75 | 146±40 | 239±23 | 417±61 |
| median | 363 | 129 | 243 | 414 |
| range | 240–459 | 129–192 | 201–262 | 348–537 |
| IGFBP-3 (ng/mL) | ||||
| mean±SD | 1803±294 | 1245±100 | 1481±197 | 1925±439 |
| median | 1824 | 1287 | 1537 | 1827 |
| range | 1307–2085 | 1131–1316 | 1145–1668 | 1469–2965 |
| ALS (ng/mL) | ||||
| mean±SD | 12180±1641 | 2964±489 | 6104±1178 | 3741±910 |
| median | 12579 | 3087 | 5891 | 3596 |
| range | 9656–14288 | 1832–3312 | 4510–7646 | 2632–4738 |
| IGF-I to IGFBP-3 molar ratio (%) | ||||
| mean±SD | 78±12 | 45±8 | 63±8 | 91±10 |
| median | 71 | 44 | 61 | 90 |
| range | 68–107 | 34–58 | 58–82 | 78–109 |
| IGFBP-3 to ALS molar ratio (%)1 | ||||
| 35 | 98 | 57 | 101 | |
| IGF-I to ALS molar ratio (%)1 | ||||
| 26 | 45 | 36 | 120 | |
1
ALS levels were from a different population. Therefore, the IGFBP-3 and IGF-I to ALS molar ratios are estimated from the mean levels for each age and sex.