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. 2008 Apr 9;3(4):e1918. doi: 10.1371/journal.pone.0001918

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Reactions were run under the conditions described in Materials and Methods on a 5% acrylamide gel and visualized using a PhosphorImager. (A) Acetylated WRN and WRN-p300 complex have higher DNA binding affinity. (B) Acetylated WRN_488–1432 has higher DNA binding activity.