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. Author manuscript; available in PMC: 2009 Mar 10.

Published in final edited form as: Brain Res. 2008 Jan 4;1198:160–170. doi: 10.1016/j.brainres.2007.12.065

a: Periventricular uptake of manganese during an infusion in a marmoset and a rat. The T₁-weighted images show projections through horizontal slices spanning the lateral ventricles in each species. A 40 mM solution of MnCl₂·4H₂0 was infused at 1.25 ml/hr and the time at the start of each image and the cumulative dry drug/body weight at that time are shown beneath the images. Arteries show bright in this type of image without manganese at 0 min. After 90 min (marmoset) or 60 min (rat) the choroid plexus (CP) shows strong enhancement. As well, enhancement can be seen in the veins and subarachnoid space surrounding the brain. After 150 min (marmoset) or 120 min (rat), strong enhancement can be seen in the parenchyma surrounding the ventricles. There is no visible enhancement in the CSF and there is no visible enhancement from the vasculature or subarachnoid space.

b: Enlarged region of marmoset brain during a manganese infusion showing periventricular (PV) uptake. The time at the start of each image and the cumulative dose of manganese given by that time are both shown. (CSF = cerebral spinal fluid.)

a: Periventricular uptake of manganese during an infusion in a marmoset and a rat. The T₁-weighted images show projections through horizontal slices spanning the lateral ventricles in each species. A 40 mM solution of MnCl₂·4H₂0 was infused at 1.25 ml/hr and the time at the start of each image and the cumulative dry drug/body weight at that time are shown beneath the images. Arteries show bright in this type of image without manganese at 0 min. After 90 min (marmoset) or 60 min (rat) the choroid plexus (CP) shows strong enhancement. As well, enhancement can be seen in the veins and subarachnoid space surrounding the brain. After 150 min (marmoset) or 120 min (rat), strong enhancement can be seen in the parenchyma surrounding the ventricles. There is no visible enhancement in the CSF and there is no visible enhancement from the vasculature or subarachnoid space.

b: Enlarged region of marmoset brain during a manganese infusion showing periventricular (PV) uptake. The time at the start of each image and the cumulative dose of manganese given by that time are both shown. (CSF = cerebral spinal fluid.)

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