Table 5. .

Results for Associated SNPs in Cohort 2

					Frequencye
SNPa	Chromosome	Positionb	Gene(s)c	Functiond	L	H	P	OR (95% CI)f	Joint Cohort Pg
rs1834640	15	46179457	…	…	.51	.87	3.28×10−15	.01 (.00–.04)	3.39×10−64
rs11070627	15	46258816	MYEF2	Up	.31	.06	1.49×10−10	54.67 (13.08–228.52)	6.63×10−41
rs12913316	15	46275146	…	…	.31	.06	2.30×10−10	46.44 (11.57–186.35)	3.18×10−41
rs16960682	15	46306954	SLC12A1	Int	.85	.97	2.32×10−6	.02 (.00–.12)	1.46×10−19
rs4775730	15	46087470	…	…	.52	.77	4.40×10−6	.14 (.06–.34)	2.10×10−25
rs2924566	15	46056053	…	…	.51	.25	6.25×10−6	6.84 (2.84–16.47)	7.65×10−27
rs9788730	15	46098702	…	…	.68	.88	7.30×10−6	.09 (.03–.27)	6.84×10−24
rs11854994	15	46986684	SHC4, DUT	Int	.72	.48	1.36×10−5	6.41 (2.67–15.39)	2.65×10−13
rs4774527	15	46971973	SHC4	Int	.84	.63	1.76×10−5	8.11 (2.96–22.2)	4.09×10−14
rs7164700	15	46097633	…	…	.8	.94	1.81×10−5	.05 (.01–.23)	3.07×10−18
rs504376	15	45957669	…	…	.58	.38	5.90×10−5	5.77 (2.36–14.09)	3.68×10−12
rs16960541	15	46157395	…	…	.87	.97	4.21×10−4	.05 (.01–.32)	1.93×10−16
rs2924567	15	46055778	…	…	.8	.64	9.62×10−4	4.7 (1.83–12.05)	1.63×10−12
rs11637235	15	46420445	DUT	Int	.59	.42	1.00×10−3	4.17 (1.72–10.06)	2.53×10−22
rs2965318	15	46051787	…	…	.31	.16	2.10×10−3	4.91 (1.73–13.9)	1.65×10−16
ss69356377	15	46157464	…	…	.9	.97	2.35×10−3	.06 (.01–.45)	1.73×10−13
rs2965317	15	46049012	…	…	.3	.15	3.50×10−3	4.79 (1.63–14.09)	1.97×10−16
rs16891982	5	33987450	SLC45A2	Nonsyn	.94	.85	4.56×10−3	7.37 (1.76–30.96)	5.02×10−13
rs784416	15	46800217	…	…	.21	.11	4.83×10−3	4.66 (1.56–13.93)	5.05×10−11
rs10519170	15	46473467	…	…	.64	.76	6.84×10−3	.28 (.11–.72)	1.03×10−16
rs1820489	15	46472393	…	…	.35	.24	6.98×10−3	3.59 (1.39–9.29)	3.71×10−15
rs2924572	15	46039330	…	…	.19	.09	1.09×10−2	5.02 (1.41–17.91)	1.85×10−11
rs1869454	15	46080741	…	…	.88	.95	1.22×10−2	.14 (.03–.68)	6.05×10−11
rs16961610	15	46847375	CEP152	Int	.81	.89	1.32×10−2	.25 (.08–.76)	2.80×10−10
rs16960450	15	46069520	…	…	.87	.95	1.98×10−2	.16 (.03–.79)	1.00×10−10
rs1042602	11	88551344	TYR	Nonsyn	.94	.87	2.05×10−2	5.05 (1.23–20.74)	6.54×10−11
rs16960453	15	46070428	…	…	.88	.95	2.38×10−2	.16 (.03–.82)	2.86×10−10
rs4775727	15	46067503	…	…	.87	.94	2.59×10−2	.18 (.04–.84)	5.38×10−11
rs16960434	15	46062007	…	…	.87	.94	2.88×10−2	.18 (.04–.87)	2.78×10−10
rs4775728	15	46078857	…	…	.88	.95	2.98×10−2	.17 (.03–.88)	1.23×10−9
rs16960451	15	46069778	…	…	.86	.94	3.04×10−2	.24 (.06–.92)	9.01×10−12
ss69356376	15	45998012	…	…	.91	.96	4.65×10−2	.17 (.03–1.01)	5.93×10−9
rs12295166	11	88615805	TYR	Int	.89	.81	8.26×10−2	2.25 (.89–5.68)	1.94×10−9
rs494230	15	45903689	…	…	.49	.6	8.44×10−2	.49 (.22–1.11)	6.24×10−10
rs2413890	15	46313654	SLC12A1	Int	.4	.31	1.85×10−1	1.77 (.76–4.14)	6.55×10−11
rs1912640	15	45774265	…	…	.17	.19	3.47×10−1	.58 (.18–1.83)	4.64×10−6
rs1843144	15	46311814	SLC12A1	Int	.3	.24	4.23×10−1	1.44 (.59–3.49)	1.26×10−7
rs4774557	15	48220992	…	…	.61	.62	4.79×10−1	.74 (.33–1.69)	6.20×10−8
rs7170781	15	48180287	ATP8B4	Int	.61	.63	5.04×10−1	.76 (.34–1.71)	1.12×10−8
rs1872304	15	46446080	…	…	.38	.36	5.60×10−1	1.28 (.55–2.99)	3.89×10−7
rs1531916	15	46313563	SLC12A1	Int	.29	.24	6.71×10−1	1.22 (.49–3.02)	1.67×10−7
rs16960843	15	46454117	…	…	.9	.91	9.46×10−1	.95 (.24–3.79)	1.55×10−6

^ars or ss identifier in dbSNP.

^bChromosome base position on NCBI build 36.2.

^cGene symbol from Entrez Gene.

^dInt = intronic; nonsyn = nonsynonymous; up = within 10 kb of the transcriptional start site.

^eFrequency of allele 1 in the reflectance groups of cohort 2.

^fOdds ratios (ORs) and 95% CIs for allele 1 are shown. The OR is the ratio of the likelihood of an individual being in the low-reflectance group to the likelihood of being in the high-reflectance group.

^gP value for the combined analysis of both cohorts.