Table 3. .
RAD51 135G→C Genotype Distribution and Estimated HRs in the Total Sample of BRCA1 and BRCA2 Mutation Carriers[Note]
| No. (%) of Carriers |
||||
| Gene and Genotype or Test |
Unaffected | With Breast Cancer | HR (95% CI) | Pa |
| BRCA1/2: | ||||
| GG | 3,485 (85.6) | 3,838 (86.4) | 1.00 | … |
| GC | 565 (13.9) | 567 (12.7) | .95 (.83–1.07) | .292 |
| CC | 19 (.5) | 38 (.9) | 1.92 (1.25–2.94) | .0008 |
| 2-df Test | … | … | … | .002 |
| Trend test | … | … | … | .801 |
| BRCA1: | ||||
| GG | 2,456 (84.6) | 2,475 (86.0) | 1.00 | … |
| GC | 429 (14.8) | 376 (13.1) | .86 (.77–1.02) | .095 |
| CC | 17 (.6) | 25 (.9) | 1.59 (.96–2.63) | .067 |
| 2-df Test | … | … | … | .046 |
| Trend test | … | … | … | .386 |
| BRCA2: | ||||
| GG | 1,036 (88.2) | 1,370 (87.0) | 1.00 | … |
| GC | 136 (11.6) | 191 (12.1) | 1.17 (.91–1.51) | .123 |
| CC | 2 (.2) | 13 (.8) | 3.18 (1.39–7.27) | .0004 |
| 2-df Test | … | … | … | .0007 |
| Trend test | … | … | … | .007 |
Note.— Compound BRCA1 and BRCA2 carriers were included in all analyses.
a
P value by the score test.