Table 4. .
RAD51 135G→C Genotype Distribution and Estimated HRs by BRCA1 and BRCA2 Mutation Class[Note]
| No. (%) of Carriers |
||||
| Mutation Class and Genotype or Test |
Unaffected | With Breast Cancer | HR (95% CI) | Pa |
| BRCA1 class 1: | ||||
| GG | 1,639 (85.8) | 1,562 (87.5) | 1.00 | … |
| GC | 262 (13.7) | 208 (11.6) | .83 (.68–1.00) | .058 |
| CC | 9 (.5) | 16 (.9) | 1.97 (1.05–3.70) | .041 |
| 2-df Test | … | … | … | .021 |
| Trend test | … | … | … | .284 |
| BRCA1 class 2: | ||||
| GG | 753 (81.9) | 825 (83.9) | 1.00 | … |
| GC | 158 (17.2) | 150 (15.3) | .93 (.74–1.17) | .567 |
| CC | 8 (.9) | 8 (.8) | 1.11 (.42–2.93) | .780 |
| 2-df Test | … | … | … | .817 |
| Trend test | … | … | … | .525 |
| BRCA2 class 1: | ||||
| GG | 995 (87.8) | 1,289 (87.0) | 1.00 | … |
| GC | 136 (12.0) | 179 (12.1) | 1.14 (.88–1.48) | .123 |
| CC | 2 (.2) | 13 (.9) | 3.24 (1.41–7.45) | .0004 |
| 2-df Test | … | … | … | .0007 |
| Trend test | … | … | … | .007 |
Note.— See main text for definition of mutation classes.
a
P value by the score test.