Figure 1. .

Hierarchical clustering of methylation data from cerebral cortex and cerebellum samples analyzed in experiment 1. Methylation profiles of 1,532 CpG sites from 24 brain samples (16 cerebella and 8 cerebra) from 24 individuals were clustered using uncentered correlation and pairwise average linkage. Columns represent samples; rows correspond to CpG sites. Two major branches are defined by our methylation data and correlate with brain region, one containing 7 of 8 cerebra and one containing 15 of 16 cerebella. A heat map showing relative methylation differences (red indicates more methylated; blue indicates less methylated) from a handful of analyzed loci is represented in the clustering dendrogram.