Figure 4. .

Hierarchical clustering of methylation data from cerebral cortex and pons samples analyzed in experiment 3. Methylation profiles of 1,505 CpG sites from 14 brain samples (7 cerebra and 7 pons) from the same individual were clustered using uncentered correlation and pairwise average linkage. Columns represent samples; rows correspond to CpG sites. Two major branches are defined by our methylation data and correlate with brain region: one containing seven of seven cerebra and one containing seven of seven pons. A heat map showing relative methylation differences (red indicates more methylated; blue indicates less methylated) from a handful of loci analyzed is represented below the clustering dendrogram.