Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nef interacts with Src, DIP, and Vav2. DIP interacts with both Nef and p190RhoAGAP, mediating Nef-Src-induced phosphorylation of p190RhoGAP. Nef interacts directly with Vav2 to induce Src-mediated Vav2 phosphorylation. The interaction between DIP and Vav2 is not required for Nef-induced Vav2 phosphorylation. Vav2 and p190 phosphorylation leads to Rac1 activation and RhoA inhibition and changes of actin cytoskeleton, as observed in HIV-infected podocytes.
