FIGURE 3.

GITR inhibited the production of proinflammatory cytokines upon activation. Purified NK cells were stimulated by poly(I-C) in the presence or absence of GITR stimulation. Two sets of data are presented side by side. In each experiment, each treatment was done in triplicates. After 48 h of culture, the triplicates were pooled, and culture supernatants were collected for cytokine analysis. The y axis represents cytokine concentration (pg/ml). Suppression percentage in each treatment was also shown.