TABLE 2.

Apoptosis occurred in IL-15 and IL-15 plus GITR treatment groups of human NK cells

Control, NK cells in culture without treatment; GITR, NK cells treated with GITR engagement for 2 days; IL-15, NK cells treated with 10 ng/ml IL-15 for 2 days; IL-15 + GITR, NK cells treated with IL-15 and GITR engagement for 2 days.

Donor number	Control	GITR	IL-15	IL-15 + GITRa
1	28.9	55.04	57	63.45
2	16.02	14.33	28.12	46.3
3	27.85	32.47	33.6	48.6
4	42.5	46	50.1	63.1
5	18.87	8.56	9.53	13.85
6	65.7	67.1	71.9	78.4
7	54.49	77.09	54.4	81.69
8	34.61	72.19	44.2	88.64
9	50	52.58	66.3	75.63
10	36.7	35.3	39.2	41.5
11	25.66	23.72	33.7	40.6
12	41	45.5	43.7	51.7
13	62	55.28	69.9	74.7
14	56.3	49.2	37.3	40.9

^aSignificant increase occurred in IL-15 plus anti-GITR treatment group compared with IL-15 treatment only (p < 0.01).