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Phosphomimetic substitutions abolish pericentromeric targeting of Ikaros. Confocal fluorescence was used to examine the subnuclear localization of wild-type (WT) and mutant Ikaros after retroviral transduction into 3T3 cells. Phosphomimetic Ikaros mutants contain substitutions with alanine or aspartate at indicated amino acids. A5 and D5 represent alanine or aspartate mutants of all 5 amino acids 13, 23, 63, 101, and 294. Single cell images are shown.
