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Normal (a) or nodular (b) wild-type rat hepatocytes transplanted into the liver of dipeptidylpeptidase type IV-deficient, syngenic hosts. Tissue samples were stained for the expression of dipeptidylpeptidase type-IV enzyme (rust-orange color). Note the diffuse, infiltrative growth pattern of normal hepatocytes in a, contrasted by the sharp demarcation between nodular and surrounding hepatocytes in b.
