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. 2008 Apr;172(4):1053–1061. doi: 10.2353/ajpath.2008.070850

Figure 2.

Figure 2

Time course of acute (A) and chronic (B) cortical de- and remyelination induced by 0.2% cuprizone in C57BL/6 mice. The extent of cortical de- and remyelination was assessed by scoring PLP-stained sections. A score of 4 represents complete myelination, whereas a score of 0 represents complete demyelination (compare to Figure 1). Significant effects versus controls are indicated by asterisks (*P < 0.05, **P < 0.01, and ***P < 0.001) and significant effects versus the preceding time point are indicated by rhombs (#P < 0.05, ##P < 0.01, and ###P < 0.001).