Skip to main content
. 2008 Apr;172(4):893–904. doi: 10.2353/ajpath.2008.070899

Figure 3.

Figure 3

Restoration of CCN6 protein in inflammatory breast cancer cells SUM149 results in up-regulation of E-cadherin protein in vivo. Mammary gland xenografts derived from SUM149/CCN6+ cells or SUM149/empty vector controls (CCN6 negative) were analyzed histologically and assayed by immunohistochemistry to investigate the expression levels of CCN6 and E-cadherin proteins. Top panels show a SUM149/vector tumor with negative CCN6 and E-cadherin proteins. Middle and bottom panels show two representative xenografts derived from SUM149/CCN6+ cells showing expression of CCN6 and a concomitant up-regulation of E-cadherin protein localized to the cell membrane. Note the gland formation in the CCN6+ xenografts best seen on the bottom panel. Magnification, ×400 and ×600.