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Cldn-153–80 decreases barrier function of intact TJs. Confluent T84 monolayers were incubated in either control medium or in the presence of 200 μmol/L Cldn-131–53, Cldn-153–80, or Cldn-1146–160 for varying amounts of time. After overnight incubation, only Cldn-153–80 significantly decreased TER, indicating that this peptide specifically increased paracellular permeability. *significantly different from control values (P < 0.05).
