Figure 1.
Anti-CD3 F(ab′)2 antibody efficiently reversed new-onset diabetes in NOD mice. Antibody preparation and injection are described in Materials and Methods. A: New-onset diabetic NOD mice were injected with anti-CD3 F(ab′)2. The diabetic untreated littermates were regarded as controls. Mice were screened for glucose levels every week after antibody treatment, and complete remission was defined as a return to normal glycemia. Results were analyzed statistically between the control group (▴, n = 15) and the antibody-treated group (▪, n = 20). B: Representative data of glucose control from four anti-CD3 F(ab′)2-treated NOD mice. Blood glucose was detected weekly after antibody treatment. A value less than 11.3 mmol/L was regarded as normal glycemic.