Table 2.
Cytokine Secretion by GM-Mac and M-Mac
| Sample | GM-Mac Mean ± SD | M-Mac Mean ± SD | P value | Fold difference |
|---|---|---|---|---|
| IL-13 | 234 ± 298 | 4420 ± 310 | 0.006 | 18.9 |
| IGF-I | 592 ± 372 | 3500 ± 616 | 0.019 | 5.9 |
| PlGF | 356 ± 310 | 1121 ± 350 | 0.037 | 3.2 |
| HGF | 340 ± 316 | 1063 ± 428 | 0.033 | 3.1 |
| GRO-α | 284 ± 493 | 873 ± 464 | 0.014 | 3.1 |
| LIGHT | 1051 ± 547 | 2796 ± 123 | 0.045 | 2.7 |
| IL-6 R | 1644 ± 1190 | 2686 ± 1278 | 0.010 | 1.6 |
| VEGF-D | 2925 ± 296 | 2493 ± 294 | 0.035 | −1.2 |
| TNF-β | 3518 ± 483 | 2425 ± 629 | 0.006 | −1.5 |
| TGF-β3 | 1685 ± 106 | 860 ± 290 | 0.043 | −2.0 |
| CCL22 | 3638 ± 1078 | 983 ± 228 | 0.045 | −3.7 |
Each of the cytokines listed was differentially secreted by the macrophage subpopulations (P < 0.05). The mean secretion from three donors is expressed in arbitrary units. A positive fold difference indicates predominance in M-Mac whereas a negative fold difference indicates predominance in GM-Mac.