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mDCs and pDCs are localized in lymphocyte aggregates in RA ST. Double-immunohistochemistry stainings were performed to investigate the distribution of CD1c (BDCA1)+ mDCs and CD304 (BDCA4)+ pDCs in relation with CD3- and CD8-positive T cells. Both mDCs and pDCs in RA synovium can be identified in close proximity to clusters of CD3- and CD8-positive cells. A representative double immunostaining of RA synovium from one patient is shown. Original magnifications, ×400.
