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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Int J Biochem Cell Biol. 2007 Aug 30;40(3):461–470. doi: 10.1016/j.biocel.2007.08.008

Fig. 6.

Fig. 6

Hypoxia-mediated XDH/XO activation and its inhibition by blocking the JAK/STAT pathway in LMVEC. A. Effect of hypoxia on the activation of XDH/XO. LMVEC were cultured and subjected to hypoxia for 2, 6, 8 and 12 h and the activation of XDH/XO was measured as described under “Experimental Procedures”. The data are presented as the means ± SE of three separate experiments. * P<0.05 versus normoxic control (time 0). B. Effect of protein inhibitors on hypoxia-induced XDH/XO activation. LMVEC were transiently transfected with SOCS3 or without transfection and then incubated with allopurinol, IL6 antibodies or AG490 individually or in combination. The LMVEC were then subjected to hypoxia for 8 h. The data are presented as the means ± SE of three separate experiments. * P<0.05 versus the normoxic control (time 0) and ** P<0.05 versus hypoxia for 8 h.