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. 2008 Feb 8;7:17. doi: 10.1186/1476-4598-7-17

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Copyright © 2008 Shi Yu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Following treatment by M1557 peptide for 40 hours, human colon cancer cell (HT-29) caspase3/7 (A), 8(B) and 9 (C) activities increased in a dose response manner. Caspase 3/7 activities in treated cancer cells increased 2–7 times compared to the untreated control cancer cells with significant effects at dose of 0.1 μM onward concentrations (P < 0.001). Caspase 8 activities in treated cancer cells also increased 2–5 times compared to the untreated control cancer cells, with significant effects at 0.1 μM onward concentrations (P < 0.001). Caspase 9 activities in treated cancer cells increased in a small scale (1.6 times), with significant effects at the higher concentrations (1 μM onward; P < 0.05) compared to caspase 3/7 and 8. Significance value: * P < 0.05; ** P < 0.001.