TABLE 1.

Electrophysiological properties of Ca_V1.2 channels containing e1b or e1c when expressed alone or co-expressed with auxiliary subunits

Combinations	I-V		Steady-state inactivation			Activation
	Ipeak density	n	V1/2,inact	ΔV1/2,inacta	n	V1/2,act	ΔV1/2,actb	n
	pA/pF		mV	mV		mV	mV
CaV1.2e1cα1/α2δ	−5.1 + 0.9	6	−9.3 + 1.8		5	−3.0 + 0.8		5
CaV1.2e1cα1/β1b/α2δ	−18.8 + 4.2c	9	−14.6 + 0.9c	−5.3	8	−7.3 + 1.6	−4.3	7
CaV1.2e1cα1/β2a/α2δ	−19.2 + 3.9c	8	−12.9 + 1.0	−3.6	7	−14.9 + 0.7c	−12.0	6
CaV1.2e1cα1/β3/α2δ	−28.6 + 6.8c	11	−19.4 + 1.3c	−10.1	8	−11.3 + 1.0c	−8.4	6
CaV1.2e1bα1/α2δ	−10.1 + 1.7d	5	−1.9 + 2.0d		5	1.5 + 1.2d		5
CaV1.2e1bα1/β1b/α2δ	−20.9 + 4.7e	8	−17.7 + 0.7e	−15.8	8	−8.1 + 1.3e	−9.6	8
CaV1.2e1bα1/β2a/α2δ	−17.1 + 3.6e	10	−14.1 + 1.4e	−12.2	9	−15.7 + 1.2e	−17.2	9
CaV1.2e1bα1/β3/α2δ	−27.1 + 5.9e	10	−16.2 + 1.7e	−14.3	7	−7.5 + 1.1d,e	−9.0	5

^aΔV_1/2,inact, β subunit-induced shift in V_1/2,inact of corresponding Ca_V1.2α₁/α₂δ channels.

^bΔV_1/2,act: β subunit-induced shift in V_1/2,act of corresponding Ca_V1.2α₁/α₂δ channels.

^cp < 0.05 Ca_V1.2e1cα₁/β/α₂δ versus Ca_V1.2e1cα₁/α₂δ.

^dp < 0.05 Ca_V1.2e1b versus corresponding Ca_V1.2e1c.

^ep < 0.05 Ca_V1.2e1bα₁/β/α₂δ versus Ca_V1.2e1bα₁/α₂δ.