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. Author manuscript; available in PMC: 2008 Nov 14.
Published in final edited form as: Eur J Pharmacol. 2007 Jul 13;573(1-3):60–64. doi: 10.1016/j.ejphar.2007.07.009

Figure 1.

Figure 1

Etomidate (A), propofol (B) and pentobarbital (C) concentration response relationship of inhibition of peak currents elicited by maximally activating concentrations of 5-HT (100µM in 5-HT3A and 300µM in 5-HT3AB receptors) mediated by 5-HT3A (closed circles) and 5-HT3AB (open squares) receptors. For each point of the 6 concentration response relationships 4 < n < 13. Error bars represent the SD of the mean relative response. Insets in each panel show two sets of representative inward currents elicited by 5-HT and mediated by 5-HT3A (top) and 5-HT3AB (bottom) receptors. The first and the third current trace of each set show the response elicited by a maximally activating concentration of 5-HT (100 µM for 5-HT3A and 300 µM for 5-HT3AB receptors) and the second trace demonstrates the effect of the anaesthetic at 300 µM on 5-HT-elicited currents. Solid and dotted lines above each current trace represent the application of 5-HT for 30 and anaesthetic for 60 s, respectively.