Table 1.
Survey of normalized IC50, Imax (% of maximal 5-HT current) and Hill slope data (±SD) of 5-HT in 5-HT3A and 5-HT3AB receptors.
DRUG | RECEPTOR | IC50[µM] | IMAX [%] | HILL COEFFICIENT |
---|---|---|---|---|
etomidate | 5-HT3A | 180 ± 86 | 96 ± 8.5 | 1.6 ± 0.86 |
5-HT3AB | 140 ± 45 | 101 ± 7.6 | 1.3 ± 0.49 | |
propofol | 5-HT3A | 370 ± 151 | 95 ± 3.3 | 1.6 ± 0.66 |
5-HT3AB | 300 ± 125 | 94 ± 3.4 | 1.4 ± 0.51 | |
pentobarbital | 5-HT3A | 520 ± 168 | 97 ± 2.9 | 1.9 ± 0.65 |
5-HT3AB | 270 ± 63 | 94 ± 3.7 | 1.7 ± 0.56 |