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. Author manuscript; available in PMC: 2008 Mar 31.
Published in final edited form as: J Biol Chem. 2007 Jan 19;282(15):11397–11409. doi: 10.1074/jbc.M607391200

FIGURE 7. Adult c-Kitpos CSCs are activated in response to ISO-induced damage.

FIGURE 7

A, c-Kitpos CSC number was elevated in the myocardium after ISO administration. *, p < 0.05 versus CTRL (B). The percentage of c-Kitpos CSCs positive for the cell cycle marker, Ki67, increased after ISO injection, peaking at 1 day. *, p < 0.05 versus CTRL. C, representative immunohistochemistry staining of c-Kitpos/Ki67pos CSCs in ISO-treated rat myocardium (c-Kit (green), Ki67 (white), α-sarcomeric actin (red), and DAPI (blue)). D, ISO exposure had no effect on CSC proliferation, measured by bromodeoxyuridine incorporation, in vitro (p = not significant).