TABLE 1.
Hemodynamic, echocardiographic, and anatomical measurements
| CTRL | ISO 1 day | ISO 3 days | ISO 6 days | |
|---|---|---|---|---|
| SBPa (mm Hg) | 93 ± 4 | 81 ± 5b | 94 ± 4 | 95 ± 4 |
| DBPc (mm Hg) | 70 ± 1 | 59 ± 5b | 69 ± 9 | 72 ± 8 |
| HRd (beats/min) | 402 ± 20 | 446 ± 20b | 408 ± 23 | 405 ± 15 |
| LVDDe (mm) | 4.7 ± 0.4 | 5.8 ± 0.1b | NDf | 5.1 ± 0.3g |
| LVSDh (mm) | 2.6 ± 0.4 | 4.3 ± 0.3b | ND | 3.1 ± 0.4g |
| Fractional shortening (%) | 45 ± 4 | 26 ± 3b | ND | 40 ± 4g |
| Ejection fraction (%) | 78 ± 6 | 57 ± 6b | ND | 72 ± 5g |
| LVEDPi (mm Hg) | 3.8 ± 1.5 | 21.0 ± 4.2b | 15.4 ± 7.4b | 10.4 ± 2.1b,g |
| LVDevPj (mm Hg) | 88.5 ± 8.2 | 64.3 ± 12.7b | 81.7 ± 9.1g | 86.7 ± 7.9g |
| dP/dtmax (mm Hg/s) | 8124 ± 1027 | 6546 ± 888b | 7576 ± 365 | 8116 ± 722g |
| dP/dtmin (mm Hg/s) | 7889 ± 1240 | 5730 ± 625b | 6739 ± 964 | 7906 ± 743g |
| LV wet weight (mg) | 767 ± 32 | 830 ± 58 | 873 ± 43b | 825 ± 26 |
| LV dry weight (mg) | 165 ± 7 | 153 ± 9 | 192 ± 7b,g | 181 ± 6b,g |
| Myocyte volume (mm3) | 12,827 ± 1612 | 13,360 ± 2600 | 20,213 ± 3664b,g | 17,132 ± 2248b |
a
Systolic blood pressure.
b
p < 0.05 versus CTRL.
c
Diastolic blood pressure.
d
Heart rate.
e
Left ventricular diastolic diameter.
f
ND, not determined.
g
p < 0.05 versus ISO 1 day.
h
Left ventricular systolic diameter.
i
LV end-diastolic pressure.
j
LV developed pressure.