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. Author manuscript; available in PMC: 2008 Mar 31.
Published in final edited form as: Brain Res Brain Res Rev. 2005 Jan 8;49(1):1–21. doi: 10.1016/j.brainresrev.2004.11.005

Fig. 3.

Fig. 3

Over-expression of Wnt-1 prevents β-amyloid (Aβ)-induced DNA fragmentation and membrane phosphatidylserine (PS) exposure in human neuroblastoma SH-SY5Y cells. Representative images of SH-SY5Y cells illustrate DNA fragmentation with terminal deoxynucleotidyl transferase nick end labeling (TUNEL) and phosphatidylserine (PS) exposure with annexin V phycoerythrin labeling in SH-SY5Y cells 24 h after administration of Aβ (20 μM). Aβ yielded significant DNA fragmentation and membrane PS exposure when compared to control untreated cultures. In contrast, overexpression of Wnt-1 results in a significant reduction in DNA fragmentation and PS exposure.