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Serum free T4 levels (mean ± sem) in rats during and after PTU treatment. Female rats (white bars) were made hypothyroid by adding PTU to the drinking water from birth until 8 wk of age. Untreated animals served as controls (black bars). At the end of the 8-wk treatment period, animals that received PTU had lower free T4 levels. Three weeks after the end of treatment, free T4 levels had increased but not normalized.
