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. 2007 Dec 27;149(4):2001–2009. doi: 10.1210/en.2007-1517

Figure 1.

Figure 1

TSHR antibodies and thyroid function in C3H/He (C3H) and C57BL/6 (B6) mice and the B6C3 F1 offspring (F1) in response to immunization with A-subunit-Ad (A-sub-Ad). Data for individual mice are presented for sera tested 1 wk after two immunizations (2×) and 4 wk after three immunizations (3×). Values for mice immunized with Con-Ad (3×) are included. A, TSHR antibodies measured by inhibition of TSH binding to its receptor (TBI). TBI values (percent) are provided for Con-Ad immunized animals (n = 10 per strain) and for A-subunit-Ad immunized animals (n = 20 per strain). Values significantly different between C3H vs. F1 and B6 after 3 immunizations: *, P < 0.05 (ANOVA). B, TSAb. Stimulation values (percent control) are for Con-Ad (n = 5 per strain) and A-subunit-Ad immunized animals (n = 10 per strain). Values significantly different: *, P < 0.05, C3H vs. F1 and B6 after two immunizations (ANOVA); #, P < 0.05, C3 vs. F1 and B6 after three immunizations (ANOVA). C, Serum T4 (μg/dl) in Con-Ad (n = 10 per strain) and A-subunit-Ad immunized animals (n = 20 per strain). Values significantly different: *, P < 0.05, C3H vs. B6 after two immunizations (ANOVA).