Table 1.
Chr associations revealed by linkage analysis for TSHR antibodies induced in BXH strains immunized with A-subunit-Ad
| Trait | LRS (LOD) | Chr | Locus | Location (Mb) | Candidate genes | Human Chr |
|---|---|---|---|---|---|---|
| TBI (2×) | 17.310 (3.76) | 17 | D17Mit83 | 34.565 | MHC region genes | 6 |
| TBI (3×) | 13.946 (3.03) | X | rs13483724 | 32.440 | Il13ra | X |
| DXMit81 | 32.633 | |||||
| 13.009 (2.83) | 17 | rs6358703 | 28.507 | MHC region genes | (6) | |
| rs6345886 | 31.110 | |||||
| TSAb (2×) | 13.628 (2.96) | 12 | rs13459138 | 113.270 | Ighg | |
| rs3705923 | 117.869 | |||||
| rs3692361 | 118.161 | |||||
| rs3679276 | 120.329 | |||||
| TSAb (3×) | 19.884 (4.32) | 9 | rs13480317 | 85.581 | (6) | |
| rs6224819 | 96.718 | (3) | ||||
| 18.642 (4.05) | 12 | rs13459138 | 113.270 | Ighg | ||
| rs3705923 | 117.869 | |||||
| rs3692361 | 118.161 | (7) | ||||
| rs3679276 | 120.329 |
Loci and their chromosomal locations are presented for traits with the highest LRS scores (LRS = LOD × 4.6) after two or three immunizations (2× or 3×). Genes of possible interest are included (italics) with the corresponding human Chr or likely corresponding human Chr (in parentheses). MHC region genes include C2 (34.470663), Hspa1 (34.577246), and Tnf (34.807461 and Ltb (34.802573). Ighg, Igγ2b constant region (113.754096); IL13ra1, IL-13 receptor-α1 (32.543583 Mb).