Table 2.
Chr associations for thyroid function traits in BXH strains before and after immunization with A-subunit-Ad
| Trait | LRS (LOD) | Chr | Locus | Mb | Potential genes | Human Chr |
|---|---|---|---|---|---|---|
| Pre-T4 | 14.533 (3.16) | 1 | rs13475947 | 80.831 | Ccl20 | 2q33-q37 |
| rs13475955 | 83.218 | |||||
| 11.954 (2.60) | 13 | rs3668922 | 112.892 | Il6st; Il31ra | 5q11.2 | |
| rs6184735 | 114.378 | |||||
| T4 (2×) | 18.932 (4.11) | 16 | rs4153199 | 5.567 | ||
| rs4162800 | 12.386 | Socs1; Litaf | 16p13 | |||
| 18.225 (3.96) | 2 | rs3675388 | 152.351 | H13; Bcl2-l1 | 20 | |
| rs13476846 | 152.723 | |||||
| T4 (3×) | 17.478 (3.80) | 8 | rs13479995 | 116.599 | (16) | |
| D8Mit271 | 117.246 | |||||
| rs13480002 | 118.038 | |||||
| 12.805 (2.78) | 3 | rs13477023 | 26.081 | Tnfsf10; Pld1 | 3 | |
| rs13477037 | 30.098 | |||||
| 12.330 (2.68) | 13 | rs3668922 | 112.892 | IL6st; Il31ra | 5q11.2 | |
| rs6184735 | 114.378 | |||||
| Δ T4 (2×) | 15.232 (3.31) | 9 | rs6183014 | 24.367 | (7) | |
| rs13480199 | 25.639 | |||||
| Δ T4 (3×) | 16.825 (3.65) | 13 | rs3668922 | 112.892 | IL6st; Il31ra | 5q11.2 |
| rs6184735 | 114.378 | |||||
| 15.006 (3.26) | 13 | rs13481789 | 43.836 | Cd83 | 6 | |
| rs3688207 | 45.370 | |||||
| 14.001 (3.04) | 3 | gnf03.027.859 | 31.138 | (3) | ||
| CEL-3_030851425 | 31.272 |
Loci and their chromosomal locations are presented for traits with the highest LRS scores (LRS = LOD × 4.6) before (pre) or after two or three immunizations (2× or 3×). Genes of potential interest are indicated (italics) with the corresponding human Chr or the likely corresponding human Chr (in parentheses). Ccl20, chemokine (C-C motif) ligand 20 (82.995805); IL6st (IL-6 signal transducer, 113.584896); IL31ra (IL-31 receptor A, 113.640776); Tnfsf10 (TNF ligand, 27.508149); Pld1 (phospholipase D1, 28.175386); Socs1 (suppressor of cytokine signaling 1, 10.69738), Litaf (LPS-induced TN factor, 10.872851); H13 (histocompatibility 13, 152.360902); Bcl2l1 (Bcl2-like 1, 152.450172); Cd83 (CD83 antigen, 43.79614).