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. 2007 Dec 27;149(4):1773–1785. doi: 10.1210/en.2007-1132

Figure 3.

Figure 3

Periweaning hyperphagia and oxidative sparing of triglycerides in AGRP:POMC:Lepr−/− mice. A, Body mass of male AGRP+POMC:Lepr−/− mice diverges quickly from control male mice immediately after weaning and rate of weight gain appears to parallel the weight gain of control mice by 9 wk of age. The increase in body mass is due to an increase in body fat, whereas lean mass was not increased. Data shown are means and sds; there were eight mice in each group for A–D. B, An analysis of meal size and meal number of postweaning AGRP+POMC:Lepr−/− male mice indicated hyperphagia is most prominent from wk 5 to wk 7. Total pellet intake was greater for the AGRP+POMC:Lepr−/− mice. Intakes during both the light and dark phases of the day are increased. C, Leptin concentrations during the postweaning period. Note the elevated leptin concentrations of AGRP+POMC:Lepr−/− mice over controls over the entire postweaning period (#, Difference of the means with P < 0.05). D, Indirect calorimetry indicates that the lower energy expenditure of young AGRP+POMC:Lepr−/− mice (open symbol) compared with control mice (filled symbol) is also associated with higher RER. #, Difference due to genotype for that time period.