Table I.
Comparison of administered dosages to recommended dosages of antimicrobials
| Category of importance to human medicinea | Antimicrobial (n; N) | Administered dose range (mg/kg; IU/kg for penicillin) | Mean administered dose (mg/kg; IU/kg for penicillin) | Mean daily labelled doseb (mg/kg; IU/kg for penicillin) | Mean administered dose/labelled dose | 95% Confidence interval |
|---|---|---|---|---|---|---|
| I | Ampicillin-sulbactamc (6; 2) | 3.43–7.11 | 6.19 | 6.6 | 0.94 | 0.77–1.10 |
| Ceftiofur (10; 2) | 0.85–1.22 | 1.11 | 1 | 1.11 | 1.03–1.20 | |
| II | Penicillind | |||||
| (40; 5) | 9 434–42 857 | 22 396 | 9 000 | 2.34 | 2.09–2.59 | |
| (15; 3) | 13 158–34 331 | 19 444 | 12 000 | 1.58 | 1.06–2.10 | |
| (50; 9) | 6 000–33 333 | 18 592 | 21 000 | 0.89 | 0.80–0.97 | |
| Tilmicosin (149; 9) | 5.50–31.25 | 10.35 | 10 | 1.05 | 1.00–1.09 | |
| Trimethoprim-sulfadoxinec (25; 9) | 1.26–37.89 | 5.24 | 2.67 | 1.97 | 0.92–3.01 | |
| III | Florfenicol (39; 9) | 7.89–40.36 | 24.45 | 40 | 0.61 | 0.55–0.68 |
| Oxytetracycline | ||||||
| 100 mg/mL (2; 1) | 0.59–0.59 | 0.59 | 6.6 | 0.09 | 0.09–0.09 | |
| 200 mg/mL (76; 13) | 1.22–27.91 | 17.64 | 20 | 0.88 | 0.83–0.94 | |
| Spectinomycin (13; 2) | 4.40–11.00 | 7.98 | 10 | 0.80 | 0.67–0.93 |
n = number of treatment diary entries for the antimicrobial; N = number of farms with treatment diary entries for the antimicrobial of the 21 farms included in this analysis.
a
Ranking of importance to human medicine (15).
b
Based on the label instructions (18).
c
Doses for combination products were set for the constituent of interest (ampicillin and trimethoprim) and combination products were placed in a category higher than their constituents as per CIPARS 2002 (8).
d
Producers often did not distinguish which penicillin product they used in the treatment diary; thus penicillin data have more uncertainty than the antimicrobial doses provided here.