Table 2.

Effect of lipopolysaccharide (LPS) endotoxaemia and treatment with glutamine on intestinal mucosal parameters.

Parameters	Control	LPS	LPS–Gln
Bowel weight (mg/cm/100 g)
Jejunum	20 ± 0·3	17 ± 1*	20 ± 0·6†
Ileum	18 ± 1	17 ± 1	20 ± 0·7*†
Mucosal weight (mg/cm/100 g)
Jejunum	9 ± 0·5	6 ± 0·5*	7 ± 0·4*
Ileum	8 ± 0·6	4·6 ± 0·3*	6·6 ± 0·4*†
Mucosal DNA (μg/cm/100 g)
Jejunum	12·3 ± 0·2	5·7 ± 1·2*	11·7 ± 0·4†
Ileum	11·7 ± 1·1	5·5 ± 1·4*	10·5 ± 0·4†
Cell proliferation (BrdU-positive cells/10 crypts)
Jejunum	142 ± 10	116 ± 2*	140 ± 3†
Ileum	156 ± 14	121 ± 6*	138 ± 4†
Cell proliferation (apoptotic cells/10 villi)
Jejunum	1·3 ± 0·2	3·2 ± 0·7*	2·7 ± 0·5*
Ileum	1·3 ± 0·5	3·0 ± 0·6*	2·3 ± 0·1

^*P < 0·05 LPS versus control

^†P < 0·05 LPS–Gln versus LPS. LPS: rats treated with LPS; LPS–Gln: rats treated with LPS and glutamine; BrdU: bromodeoxyuridine.