Figure 6.

A, dose-dependent effect of 1 nmol l⁻¹ (n = 34) and 100 nmol l⁻¹ Ang II (n = 14) on superoxide generation by myocardial slices. Ang II (1 and 100 nmol l⁻¹) significantly increased superoxide production above the control lucigenin level (tissue minus background) (P < 0.05). The effect of 100 nmol l⁻¹ Ang II was abolished in the presence of losartan (Los, n = 5) and MPG (n = 3) blunted the superoxide production induced by 1 nmol l⁻¹ Ang II. B, luminescence values of the tissue in the absence of drugs (Control, n = 32), and in the presence of Los (n = 8) and MPG (n = 7). Note that the basal value was unaffected by the scavenger MPG, demonstrating that it was not due to a basal ·O₂⁻ production by the tissue.