Table 5.
Fetal environment and growth and arginine-stimulated insulin secretion
Fetal environmental measure immediately before experiment | Fetal endocrine responses to environment | Fetal and placental growth | |||||||
---|---|---|---|---|---|---|---|---|---|
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O2 content | Plasma glucose | Plasma insulin | Plasma cortisol | Fetal weight | Placental weight | Fetal: placental weight | |
122 days gestation | |||||||||
Plasma AAN | NS | 0.424 | NS | NS | NS | −0.375 | 0.496 | NS | NS |
0.031 | 0.069 | 0.043 | |||||||
20 | 17 | 13 | |||||||
Plasma insulin | NS | NS | NS | 0.457 | — | NS | 0.691 | 0.673 | −0.514 |
0.021 | 0.004 | 0.006 | 0.036 | ||||||
20 | 13 | 13 | 13 | ||||||
Plasma insulin:AAN | NS | NS | NS | 0.440 | — | NS | 0.435 | 0.709 | − 0.612 |
0.026 | 0.069 | 0.003 | 0.013 | ||||||
20 | 13 | 13 | 13 | ||||||
AAN AUC | NS | −0.372 | −0.349 | NS | −0.315 | NS | −0.537 | −0.495 | 0.519 |
0.059 | 0.072 | 0.095 | 0.036 | 0.051 | 0.042 | ||||
19 | 19 | 19 | 12 | 12 | 12 | ||||
Insulin AUC | −0.302 | NS | NS | 0.390 | 0.556 | NS | NS | 0.423 | NS |
0.098 | 0.044 | 0.005 | 0.075 | ||||||
20 | 20 | 20 | 13 | ||||||
Insulin secretion | −0.394 | NS | NS | 0.340 | 0.523 | NS | NS | 0.431 | − 0.484 |
0.048 | 0.077 | 0.011 | 0.081 | 0.056 | |||||
19 | 19 | 19 | 12 | 12 | |||||
140 days gestation | |||||||||
Plasma AAN | NS | 0.650 | 0.650 | NS | 0.406 | NS | 0.570 | NS | NS |
0.002 | 0.002 | 0.047 | 0.013 | ||||||
18 | 17 | 18 | 15 | ||||||
Plasma insulin | NS | 0.650 | 0.650 | NS | 0.406 | NS | 0.570 | NS | NS |
0.002 | 0.002 | 0.047 | 0.013 | ||||||
18 | 17 | 18 | 15 | ||||||
Plasma insulin: AAN | NS | 0.630 | 0.543 | 0.699 | — | NS | 0.562 | NS | NS |
0.002 | 0.010 | < 0.001 | 0.012 | ||||||
19 | 18 | 19 | 16 | ||||||
AAN AUC | NS | NS | NS | 0.656 | — | NS | NS | 0.442 | −0.351 |
0.002 | 0.049 | 0.100 | |||||||
18 | 15 | 15 | |||||||
Insulin AUC | NS | −0.612 | −0.414 | −0.619 | −0.617 | NS | −0.806 | NS | NS |
0.003 | 0.049 | 0.003 | 0.003 | < 0.001 | |||||
18 | 17 | 18 | 18 | 15 | |||||
0.396 | NS | NS | 0.720 | 0.590 | −0.452 | NS | NS | NS | |
0.047 | < 0.001 | 0.004 | 0.052 | ||||||
19 | 19 | 19 | 14 | ||||||
Insulin secretion | NS | NS | NS | 0.787 | 0.631 | NS | 0.454 | 0.375 | NS |
< 0.001 | 0.002 | 0.045 | 0.084 | ||||||
18 | 18 | 15 | 15 |
Data are shown as r, p, n for each correlation.