Figure 6. Effects of nicardipine on spontaneous Ca2+ transients recorded from USMCs and ICC-LCs in the urethra.
Aa, spontaneous Ca2+ transients recorded form USMCs of the rabbit urethra were strongly suppressed by nicardipine (1 μm) (Ab). Ba, in another preparation, ICC-LC Ca2+ transients generated spontaneous Ca2+ transients which were not inhibited by nicardipine (1 μm) (Bb). C, summary of the effects of nicardipine on ICC-LC Ca2+ transients. Nicardipine (1 μm) did not significantly change amplitude (a), frequency (b) or half-width (c) of ICC-LC Ca2+ transients.