Figure 10. Role of nitrergic and α-adrenergic stimulation in the modulation of spontaneous Ca²⁺ transients recorded from the urethral ICC-LCs.

SIN-1 (10 μm;A) reduced the amplitude (Ba) of spontaneous Ca²⁺ transients recorded from ICC-LC, but did not significantly alter either their frequency (Bb) or half-width (Bc). Ca, in another preparation, bath-applied phenylephrine (1 μm) increased the frequency of spontaneous Ca²⁺ transients recorded from ICC-LC and raised basal Ca²⁺ levels. b, a higher concentration of phenylephrine (10 μm) further accelerated ICC-LC Ca²⁺ transients which summed to create a sustained rise in the basal Ca²⁺ concentration.